《大明嫔妃 第1部》是由陈晓雷执导，宋洋,何杜娟,关慧卿,赵家林主演的国产剧。该电视剧于2010年在大陆上映。《大明嫔妃》讲述了明朝第十四个皇帝朱常洛的后宫嫔妃的故事，叙述了朱常洛多情而又传奇的一生。 皇太子争选太子妃，兰心本有所爱，奴婢梅儿为了好姐妹兰心代替她进入太子府。不料被揭穿。兰心则不得不进到太子府，因为才华出众，深得皇太子和王恭妃的喜爱，兰心被嫉妒和排挤，在太子府里受尽磨难！亏梅儿以身为其遭受苦难。 其实一切阴谋都是秀女姚芊芊设计的，姚芊芊是郑贵妃的人，自己参选秀女就是为了接近太子，协助郑贵妃铲除太子，虽然她心中也另有所爱，但不得不去争选太子妃，铲除一切阻碍自己当上太子妃的秀女。 姚芊芊陷害兰心通奸，差点害的兰心被赐死，关键时刻兰心被梅儿所救。几日后公布太子妃人选之时，王恭妃为了顾全大局，还是让姚芊芊当上了太子妃，姚芊芊十分痛苦内心挣扎，兰心、梅儿、金碧瑶当上侧妃，大家各怀想法。
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