《四大金钗》是由吴宗宪执导,莫少聪,吴宗宪,雪村主演的喜剧片。该电影于2007年在大陆上映。傻里傻气的二师兄(吴宗宪饰)少林学到高深武功归来创办怡红镖局,严重口吃的大师兄(NONO饰)、最爱恶作剧的大小姐(吴辰君饰)也加入护镖,镖局开门就热闹非凡,誓将要饭文化进行到底的丐帮之女(谢娜饰)偶来看热闹,却爱上了傻二师兄,害人不利己的五毒门大哥(雪村饰)也常来捣蛋。外敌入侵,皇帝(莫少聪饰)决定献出国宝夜明珠以求安宁,遂派怡红镖局护宝救国。奸丞为篡夺皇位便设计陷害大师兄、二师兄都未能得逞,最后勾结五毒门用千手观音体操掌打伤二师兄后抢劫夜明珠。而怡红镖局因大师兄口吃闹笑话而连带二师兄被抓,并约定一炷香之后尚未看到国宝就要进军中原,丐帮之女发动丐帮及一些武林人士全力营救,在惨烈的打斗后都未能成功,这时,隐侠出现了,一场恶战就要开始,搞笑故事也拉开了序幕……
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