《初恋50次》是由彼得·西格尔执导，德鲁·巴里摩尔,陈英明,西恩·奥斯汀,罗伯·施奈德主演的剧情片。该电影于2004年在美国上映。亨利是夏威夷水族馆的一名兽医，也是一位快乐的单身汉。一次偶然的机会，在一个小饭馆中，他遇到了让自己怦然心动的女孩露西(德鲁·巴里摩尔饰)。经过交谈，一对年轻男女迅速迸出热情的火花。整夜春光之后，亨利满怀深情地对着刚睁开睡眼的露西送上早安问候，谁知道回报他的却是惊恐的尖叫和不顾一切的殴打。经过多方打听，亨利终于了解到，露西因为一次车祸而患上了一种极为罕见的短期记忆丧失症。当第二天太阳升起的时候，她就会把前一天的事情全都忘光。坠入情网的亨利无法放弃自己心爱的女孩，开始了既疯狂又令人感动的追求计划——务求在每天太阳升起，每一个新的一天来临之时，让露西再一次爱上他。
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