《X医生：外科医生大门未知子 第2季》是由田村直己,松田秀知执导，米仓凉子,藤木直人,内田有纪,远藤宪一,满岛真之介,笛木优子,水泽绘玲奈,猪野学,野间口彻,六角慎司,浅野和之,笹野高史,岸部一德,三田佳子,西田敏行主演的日韩剧。该电视剧于2013年在日本上映。在上一季中，以果敢干练的作风和高超惊人的医术，人称“DoctorX”外科医生大门未知子（米仓凉子饰）在早已形同腐臭泥潭一般的帝都医科大学第三医院力挽狂澜，掀起前所未有的风暴。因在北海道马场冒险为一匹骨折的马做手术，未知子得到内科专家马渊一代（三田佳子饰）的赏识，进而受邀踏入全日本顶尖医者云集的殿堂——帝都医科大学附属医院！此前不久，外科总负责人蛭间重盛（西田敏行饰）曾亲手为医院的大金主——某地产大鳄二宫钦也（寺田农饰）完成高危手术，谁知此番二宫癌症复发再度入院。第二外科主任海老名（远藤宪一饰）携团队积极备战，配合蛭间迎接新一轮的手术。而马渊所率领的内科则就治疗方式上与外科产生严重分歧和对立。未知子的到来，无疑使双方的矛盾趋于白热化……
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