金翅雕因为作恶多端而被封印在高塔之中上千年，为了恢复昔日的邪恶力量， 利用月食之夜复活了蛇蝎二妖，利用法力将葫芦山分崩离析，向七个方位飞去。 金翅雕命令蛇蝎寻找葫芦七兄弟练成七心丹帮助自己解除封印，重获法力和自由。蛇蝎二妖在它的帮助下拥有了更为强大的法力，发誓要找到七兄弟报镇压之仇，于是派出了妖怪头领计划将葫芦兄弟逐个攻破。 与此同时，葫芦山神洞察了妖怪们的阴谋，及时复活了爷爷和穿山甲并嘱咐他们尽快找回葫芦七兄弟，只有他们才能阻止妖怪的计划。于是爷爷和穿山甲带着山神给的神秘锦囊踏上了寻找七兄弟的旅途。 七兄弟分散之后失去了记忆，他们各自又会遭遇怎样的境况？
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