《达芬奇的恶魔第二季》是由查尔斯·斯特里奇执导，汤姆·莱利,格雷格·奇林,艾略特·科万,塞林·琼斯,Stephen,Marzella,罗斯·奥亨尼西,劳拉·普沃,维利贝·托皮奇,Gioacchino,Jim,Cuffaro,Isabella,Blake-Thomas,海拉·西尔玛,布莱克·瑞特森,阿兰·柯德勒,詹姆斯·福克纳,亚历山大·希迪格,克瑞恩·比尤主演的欧美剧。该电视剧于2014年在美国上映。第二季中汤姆·莱利饰演的达芬奇为拯救陷入萨帕兹家族的阴谋叛乱危机的佛罗伦城，和同时受了重伤的洛伦佐。达芬奇将挑战身体和精神的极限来保卫来自罗马势力侵袭的佛罗伦城。与此同时，美第奇家族将面临无法置信的新一轮威胁，达芬奇也将继续踏上了他使命之路去寻找《叶之书》，去揭开他母亲的过去历史未知真相。达芬奇很快就意识到等待他前面的是致命的使命挑战 — 比西斯教皇更强劲的敌人！他的探索将带他到异国他乡，重新估价他对世界的认识以及对自我过去的评价。
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