在永远为白雪覆盖的科罗拉多小镇,生活着一群想法独特、行事怪异的小孩。经常充当四人组领导者的斯坦(特瑞·帕克 Trey Parker 配音)对流行元素永远抱怀疑态度,而面对喜欢的女孩又会忍不住呕吐;戴着绿色帽子的犹太小孩凯尔(麦特·斯通 Matt Stone 配音)因种族的关系经常和抱有歧视且贪婪自大的超级毒舌小胖子艾瑞克(Trey Parker 配音)发生冲突;永远裹得严严实实说话含混不清的肯尼(Matt Stone 配音),很悲惨地每集都死于意外,而下一集又若无其事地复活。四个小家伙以及镇上各种思想扭曲的人物、时不时乱入的名人。组成了妙语连珠、恶搞不断的南方公园大世界……
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