《大明嫔妃之逐鹿》是由田少波执导,宋洋,何杜娟,朱一龙,陈一诺主演的国产剧。该电视剧于2010年在中国大陆上映。处死朱由桦的当天,朱由桦离奇失踪,梅儿和兰心都因此受到责罚。兰心不顾太子反对,执意要将朱由桦送还给三皇子,却发现马车上的孩子竟然不翼而飞。兰心和太子感情出现嫌隙,梅儿和金碧瑶使出浑身解数争得太子宠爱。太子和万历等人到郊外狩猎,有人暗杀太子,梅儿为太子挡下一箭,生命垂危,太子深受感动,认为欠梅儿太多。上官鸿业调查太子行刺事件,却发现幕后的真凶并不是众人猜想的三皇子,而是梅儿。梅儿册封当天,郑贵妃揭出了梅儿乃娼妓之女的秘密,让梅儿不能受封。郑贵妃趁势发动自己的亲信弹劾上官鸿业,兰心救父心切,却误会太子,两人再次不欢而散。失踪多日的朱由桦突然出现在兰心房中,将朱由桦放入篮子中带入宫去,却被梅儿换成了旋儿,兰心带“朱由桦,”进宫,巧遇为上官鸿业来求情的太子,太子再次产生了误会。在王恭妃和郑贵妃的逼迫下,太子提剑杀死了璇儿 ,等知道时璇儿已经没有了呼吸。兰心伤心欲绝。兰心带幸存的朱由桦离去,太子策马追去,却寻不见踪影了。皇上以太子妃一位不可久缺为由,册封大学士王中泽之女王氏为太子妃。
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