《锦衣卫马伊琍版》是由张黎执导,马伊琍,王茂蕾,文章,谭凯,刘文治,黄志忠,李强,王劲松主演的国产剧。该电视剧于2006年在大陆上映。故事发生在明朝末年,泰昌帝朱常洛(刘文治 饰)老来得子,既皇三子朱由校,遂即引起太子位之争。杀手入宫刺杀皇子,锦衣卫校尉杨天石(谭凯 饰)拼死力保,但皇子生母仍被杀害,杀手萧云天(王九胜 饰)自尽。由于宫禁失察,钱仕达(马少骅 饰)及魏公公(李迎旗 饰)均遭责罚,他们找 来京师美女客印月(马伊俐 饰)做皇子的乳娘,而客印月先前遭李进忠奸污(黄志忠 饰)生下一子,被杨天石所救,二人萌生刻骨爱意。不料皇帝见客印月貌似天仙,把她封为奉圣夫人留在后宫,之后十六年未能见情人杨天石一面。印月所生之子被天石养大,取名布衣(王茂蕾 饰),而李进忠则自宫为太监,拜魏公公为义父,更名魏忠贤。辽东事变后,自小心灵扭曲的朱由校(文章 饰)乱伦奸污乳娘客印月,客印月无奈逃出皇宫,流亡江南……
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