《第一次的离别》是由王丽娜执导，艾萨·亚森,凯丽比努尔·热合米图力,艾力乃孜·热合米图力,穆萨·亚森,亚森·卡斯木,乌古来木·苏吾尔,塔杰古丽·海麦尔,热合米图力·克然木,克然木·喀斯木主演的剧情片。该电影于2020年在大陆上映。故事发生在地大物博风景壮丽的新疆，艾萨是一个从小到大都在这里长大的土生土长的新疆男孩。艾萨出生在一个并不富裕的家庭之中，母亲的患病让家里的经济条件雪上加霜，母亲的病不仅让她丧失了语言功能，还常常会离家出走不见踪迹，因此艾萨必须在上学之余格外小心的看护随时都会发生状况的母亲，因为艾萨深深的爱着自己的母亲，所以这点苦他从来都不放在心上。 凯丽比努尔是艾萨虽好的朋友，艾萨遇到了什么烦心事第一个想到的就是和她倾诉，两人还共同养育着一只小羊。人生海海，每一步都是两人相互扶持着走过，一路上留下最美好的回忆。
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